Sam Rockwell Mr. Wolf (voice) Marc Maron Mr. Snake (voice) Awkwafina Ms. Tarantula (voice) Craig Robinson Mr. Shark (voice) Anthony Ramos Mr. Piranha (voice) Richard Ayoade Professor Marmalade (voice) Zazie Beetz Diane Foxington (voice) Alex Borstein Police Chief Misty Luggins (voice) Lilly Singh Tiffany Fluffit (voice) Barbara Goodson Old Lady (voice) Dina Morrone Museum Announcer / Diane's A.I. Assistant (voice) Michael Godere Delivery Driver / Museum Guest 1 (voice) Walt Dohrn Scientist / Gala Guest 3 (voice)