Leonardo DiCaprio Ernest Burkhart Lily Gladstone Mollie Burkhart Robert De Niro William Hale Jesse Plemons Tom White Tantoo Cardinal Lizzie Q Cara Jade Myers Anna JaNae Collins Reta Jillian Dion Minnie Jason Isbell Bill Smith William Belleau Henry Roan John Lithgow Prosecutor Peter Leaward Brendan Fraser W.S. Hamilton Scott Shepherd Byron Burkhart Louis Cancelmi Kelsie Morrison Tatanka Means John Wren Tommy Schultz Blackie Thompson Sturgill Simpson Henry Grammer Ty Mitchell John Ramsey Gary Basaraba Detective Burns Charlie Musselwhite Alvin Reynolds Pat Healy Agent John Burger Steve Witting Dr. James Shoun Steve Routman Dr. David Shoun Gene Jones Pitts Beatty Michael Abbott Jr. Agent Frank Smith J. C. MacKenzie Radio Announcer Barry Corbin Undertaker Turton Victor McCay Photos Hustler #2 Justin France Card Player Elden Henson Duke Burkhart Joey Oglesby Roy Bunch Lee Eddy Mrs. Mackie James Healy Jr. 2nd Insurance Man Steve Eastin Judge John C. Pollock Joe Chrest Lawyer Freeling Welker White Radio Voice (Hale's relative)