Ryan Reynolds Wade Wilson / Deadpool Hugh Jackman Logan / Wolverine Emma Corrin Cassandra Nova Matthew Macfadyen Mr. Paradox Morena Baccarin Vanessa Rob Delaney Peter Leslie Uggams Blind Al Karan Soni Dopinder Brianna Hildebrand Negasonic Teenage Warhead Shioli Kutsuna Yukio Stefan Kapicic Colossus (voice) Randal Reeder Buck Lewis Tan Shatterstar Aaron Stanford John Allerdyce / Pyro Jennifer Garner Elektra Natchios / Elektra Dafne Keen Laura Kinney / X-23 Wesley Snipes Eric Brooks / Blade Channing Tatum Remy LeBeau / Gambit Chris Evans Johnny Storm / Human Torch Jon Favreau Happy Hogan Wunmi Mosaku Hunter B-15 Tyler Mane Sabretooth Aaron W Reed Juggernaut Ray Park Mortimer Toynbee / Toad Jason Flemyng Azazel Dania Ramirez Callisto Tony McCarthy Barman Sonita Henry Mrs. Chipman Ryan McKen Mr. Chipman Leemore Marrett Jr. Minuteman Leader James Dryden TVA Tech Ollie Palmer Bar Patron Greg Hemphill Seedy Bartender Rob McElhenney TVA Soldier Ed Kear Outpost Tech Paul G. Raymond TVA Office Agent Henry Cavill Cavillrine Blake Lively Ladypool (voice) Nathan Fillion Headpool (voice) Matthew McConaughey Cowboypool (voice) Paul Mullin Welshpool (voice) Alex Kyshkovych Canadapool (voice) Chris Hemsworth Thor (uncredited) Mark Ruffalo Hulk (uncredited)