Johnny Depp Rango (voice) Isla Fisher Beans (Voice) Ned Beatty Mayor Tortoise John (voice) Bill Nighy Rattlesnake Jake (voice) Alfred Molina Roadkill (voice) Abigail Breslin Priscilla (voice) Claudia Black Angelique (voice) Timothy Olyphant The Spirit of the West (voice) Ray Winstone Bad Bill (voice) Stephen Root Doc / Merrimack / Mr. Snuggles (voice) Harry Dean Stanton Balthazar (voice) Ian Abercrombie Ambrose (voice) Gil Birmingham Wounded Bird (voice) James Ward Byrkit Waffles / Gordy / Papa Joad / Cousin Murt / Curlie / Knife Attacker / Rodent Kid (voice) Blake Clark Buford (voice) Keith Campbell Sod Buster (voice) Beth Grant Bonnie (voice) John Cothran, Jr. Elgin (voice) Patrika Darbo Delilah / Maybelle (voice) George DelHoyo Señor Flan (voice) Maile Flanagan Lucky (voice) Charles Fleischer Elbows (voice) Ryan Hurst Jedidiah (voice) Vincent Kartheiser Ezekiel / Lasso Rodent (voice) Lew Temple Furgus / Hitch (voice) Alanna Ubach Boo / Cletus / Fresca / Miss Daisy (voice)