Steve Carell Gru (voice) Kristen Wiig Lucy (voice) Benjamin Bratt Eduardo 'El Macho' Pérez (voice) Miranda Cosgrove Margo (voice) Russell Brand Dr. Nefario (voice) Ken Jeong Floyd Eagle-san (voice) Steve Coogan Silas Ramsbottom (voice) Elsie Fisher Agnes (voice) Dana Gaier Edith (voice) Moisés Arias Antonio Pérez (voice) Nasim Pedrad Jillian (voice) Kristen Schaal Shannon (voice) Pierre Coffin Kevin / Bob / Stuart / Additional Minions / Evil Minions (voice) Chris Renaud Additional Minions / Evil Minions / Italian Waiter (voice) Nickolai Stoilov Arctic Lab Guards (voice) Vanessa Bayer Flight Attendant (voice) Ava Acres Additional Voices (voice) Lori Alan Additional Voices (voice) Jack Angel Additional Voices (voice) Eva Bella Additional Voices (voice) Georgia Cook Additional Voices (voice) John Cygan Additional Voices (voice) Debi Derryberry Additional Voices (voice) Jess Harnell Additional Voices (voice) Danny Mann Additional Voices (voice) Mona Marshall Additional Voices (voice) Mickie McGowan Additional Voices (voice) Mason McNulty Additional Voices (voice) Alec Medlock Additional Voices (voice) Laraine Newman Additional Voices (voice) Jan Rabson Additional Voices (voice) Andre Robinson Additional Voices (voice) Katie Silverman Additional Voices (voice) Casey Simpson Additional Voices (voice) Jim Ward Additional Voices (voice) April Winchell Additional Voices (voice)