Diego Luna Manolo (voice) Channing Tatum Joaquin (voice) Zoe Saldana Maria (voice) Christina Applegate Mary Beth (voice) Eugenio Derbez Chato (voice) Cheech Marin Pancho Rodriguez (voice) Gabriel Iglesias Pepe Rodriguez (voice) Ron Perlman Xibalba (voice) Kate del Castillo La Muerte (voice) Ana de la Reguera Carmen Sánchez (voice) Dan Navarro Chakal (voice) Ice Cube Candle Maker (voice) Héctor Elizondo Carlos Sanchez (voice) Danny Trejo Skeleton Luis (voice) Carlos Alazraqui General Posada / Dali / Chuy (voice) Elijah Rodriguez Young Joaquin Plácido Domingo Skeleton Jorge (voice) Grey DeLisle Grandmother (voice) (as Grey Griffin) Miguel Sandoval Land of the Remembered Captain (voice) Jorge R. Gutierrez Skeleton Carmelo (voice) Anjelah Johnson-Reyes Adelita / Nina (voice) Gunnar Sizemore Ignacio (voice) Angélica María Sister Ana (voice) Eva Bella Additional Voices (voice) Al Rodrigo Additional Voices (voice) David Cowgill Additional Voices (voice) Elisa Gabrielli Additional Voices (voice)