Justice Smith Tim Goodman Ryan Reynolds Detective Pikachu (voice) Kathryn Newton Lucy Stevens Bill Nighy Howard Clifford Ken Watanabe Lieutenant Hide Yoshida Chris Geere Roger Clifford Suki Waterhouse Ms. Norman Rita Ora Dr. Ann Laurent Karan Soni Jack Omar Chaparro Sebastian Josette Simon Grams Simone Ashley Girlfriend Alejandro De Mesa Bartender Ben Fox Lead Cop Max Fincham Young Tim Goodman Diplo DJ Edward Davis Boyfriend Kadiff Kirwan Mayor Ryoma Takeuchi Male Pokémon Trainer Rina Hoshino Mewtwo (voice) Ikue Otani Pikachu (voice) Kotaro Watanabe Mewtwo (voice)