Milla Jovovich Alice Michelle Rodriguez Rain Ocampo Eric Mabius Matt Addison James Purefoy Spence Parks Martin Crewes Chad Kaplan Colin Salmon James "One" Shade Pasquale Aleardi J.D. Salinas Heike Makatsch Dr. Lisa Addison Ryan McCluskey Mr. Grey Indra Ové Ms. Black Oscar Pearce Mr. Red Anna Bolt Dr. Green Joseph May Dr. Blue Robert Tannion Dr. Brown Jaymes Butler Clarence Stephen Billington Mr. White Fiona Glascott Ms. Gold Liz May Brice Medic Michaela Dicker Red Queen Jason Isaacs Dr. William Birkin (uncredited)