Tobey Maguire Spider-Man / Peter Parker Willem Dafoe Green Goblin / Norman Osborn Kirsten Dunst Mary Jane Watson James Franco Harry Osborn Cliff Robertson Ben Parker Rosemary Harris May Parker J.K. Simmons J. Jonah Jameson Joe Manganiello Flash Thompson Gerry Becker Maximilian Fargas Bill Nunn Joseph 'Robbie' Robertson Jack Betts Henry Balkan Stanley Anderson General Slocum Ron Perkins Dr. Mendel Stromm Michael Papajohn Carjacker K. K. Dodds Simkins Ted Raimi Hoffman Bruce Campbell Ring Announcer Elizabeth Banks Miss Brant John Paxton Houseman Tim DeZarn Philip Watson Taylor Gilbert Madeline Watson Randy Poffo Bone Saw McGraw Larry Joshua Wrestling Promoter Timothy Patrick Quill Wrestling Arena Guard Natalie T. Yeo Bone-ette Jim Ward Project Coordinator Octavia Spencer Check-In Girl Ajay Mehta Cabbie Matt Smith Cop at Carjacking Lucy Lawless Punk Rock Girl Jim Norton Surly Truck Driver Stan Lee Man in Fair (uncredited) Scott L. Schwartz Screaming Wrestler (uncredited) Jophery C. Brown Chef (uncredited) Mark De Alessandro Cop (uncredited)