Steve Carell Gru / Chet (voice) Kristen Wiig Lucy Wilde / Blanche (voice) Joey King Poppy Prescott (voice) Will Ferrell Maxime Le Mal (voice) Sofía Vergara Valentina (voice) Miranda Cosgrove Margo / Bree (voice) Dana Gaier Edith / Blair (voice) Madison Polan Agnes / Britney (voice) Pierre Coffin Minions (voice) Steve Coogan Silas Ramsbottom (voice) Stephen Colbert Perry Prescott (voice) Chloe Fineman Patsy Prescott (voice) Brad Ableson Sensei O'Sullivan (voice) John DiMaggio Bus Driver (voice) Chris Renaud Additional Minions (voice) (uncredited) Jason Segel Vector (voice) (uncredited) Benjamin Bratt El Macho (voice) (uncredited) Trey Parker Balthazar Bratt (voice) (uncredited) Sandra Bullock Scarlet Overkill (voice) (uncredited) Jon Hamm Herb Overkill (voice) (uncredited) Taraji P. Henson Belle Bottom (voice) (uncredited) Russell Brand Dr. Nefario (voice) (uncredited) Tara Strong Felonious Gru Jr. (voice)