Steve Carell Gru (voice) Jason Segel Vector (voice) Russell Brand Dr. Nefario (voice) Julie Andrews Gru's Mother (voice) Will Arnett Mr. Perkins (voice) Kristen Wiig Miss Hattie (voice) Miranda Cosgrove Margo (voice) Dana Gaier Edith (voice) Elsie Fisher Agnes (voice) Pierre Coffin Tim / Bob / Mark / Phil / Stuart (voice) Chris Renaud Dave (voice) Jemaine Clement Jerry (voice) Jack McBrayer Carnival Barker / Tourist Dad (voice) Danny McBride Fred McDade (voice) Mindy Kaling Tourist mom (voice) Rob Huebel Anchorman (voice) Ken Daurio Egyptian Guard (voice) Ken Jeong Talk Show Host (voice) Katie Leigh Additional Voices (voice) Ranjani Brow Additional Voices (voice) Scott Menville Additional Voices (voice) Edie Mirman Additional Voices (voice) Al Rodrigo Additional Voices (voice)