Shia LaBeouf Sam Witwicky Rosie Huntington-Whiteley Carly Josh Duhamel Lennox John Turturro Simmons Tyrese Gibson Epps Patrick Dempsey Dylan Frances McDormand Mearing John Malkovich Bruce Brazos Kevin Dunn Ron Witwicky Julie White Judy Witwicky Alan Tudyk Dutch Ken Jeong Jerry Wang Glenn Morshower General Morshower Lester Speight Eddie Buzz Aldrin Self Bill O'Reilly Self Ravil Isyanov Voshkod Markiss McFadden Lennox Team 'Baby Face' Scott C. Roe Lennox Team 'Nelson' James D. Weston II Lennox Team 'Tuens' Mikal Vega Epps Team 'Hooch' Kenny Sheard Epps Team 'Marc L' Josh Kelly Epps Team 'Stone' Keiko Agena Mearing's Aide LaMonica Garrett Morshower's Aide Yasen Peyankov Voshkod Associate Elya Baskin Cosmonaut Dimitri Mindy Sterling Female Insurance Agent Maile Flanagan Accuretta Worker Leonard Nimoy Sentinel Prime (voice) Jess Harnell Ironhide (voice) Charlie Adler Starscream (voice) James Remar Sideswipe (voice) Tom Kenny Wheelie (voice) Frank Welker Shockwave / Soundwave / Barricade (voice) Ron Bottitta Roadbuster / Amp (voice) John DiMaggio Leadfoot / Target (voice)