Tom Holland Peter Parker / Spider-Man Samuel L. Jackson Nick Fury Jake Gyllenhaal Quentin Beck / Mysterio Marisa Tomei May Parker Jon Favreau Harold 'Happy' Hogan Zendaya Michelle 'MJ' Jones Jacob Batalon Ned Leeds Tony Revolori Eugene 'Flash' Thompson Angourie Rice Betty Brant Remy Hii Brad Davis Martin Starr Mr. Harrington J.B. Smoove Mr. Dell Jorge Lendeborg Jr. Jason Ionello Cobie Smulders Maria Hill Numan Acar Dimitri Zach Barack Zach Zoha Rahman Zoha Yasmin Mwanza Yasmin Joshua Sinclair-Evans Josh Spinelli Tyler Luke Cunningham Tyler Sebastián Viveros Sebastian Toni Garrn The Seamstress Peter Billingsley William Ginter Riva Clare Dunne Victoria Nicholas Gleaves Guterman Claire Rushbrook Janice J.K. Simmons J. Jonah Jameson Dawn Michelle King E.D.I.T.H. (voice) Pat Kiernan Himself Jeff Bridges Obadiah Stane (archive footage) (uncredited) Massi Furlan Flight Attendant (uncredited) Sonia Goswami Tourist (uncredited) Joseph Long Mob Boss (uncredited) Ben Mendelsohn Talos (uncredited) Anthony Molinari Mob Guy (uncredited) Hiten Patel British Station Staff (uncredited) Annie Pisapia Traveler (uncredited)