Ron Perlman Hellboy John Hurt Prof. Bruttenholm Selma Blair Liz Sherman Rupert Evans John Myers Jeffrey Tambor Tom Manning Doug Jones Abe Sapien Karel Roden Grigori Rasputin Brian Steele Sammael Ladislav Beran Karl Ruprecht Kroenen Biddy Hodson Ilsa Haupstein Corey Johnson Agent Clay Brian Caspe Agent Lime James Babson Agent Moss Kevin Trainor Young "Broom" Stephen Fisher Agent Quarry Angus MacInnes Sgt. Whitman Jim Howick Cpl. Matlin Rory Copus Kid on Rooftop Santiago Segura Train Driver David Hyde Pierce Abe Sapien (voice) (uncredited) Tara Hugo Doctor Jenkins Andrea Miltner Doctor Marsh